Uncoordinated (UNC)119: Coordinating the trafficking of myristoylated proteins

The Caenorhabditis elegans unc-93 gene encodes a putative transmembrane protein that regulates muscle contraction

unc-93 is one of a set of five interacting genes involved in the regulation or coordination of muscle contraction in Caenorhabditis elegans. Rare altered-function alleles of unc-93 result in sluggish movement and a characteristic "rubber band" uncoordinated phenotype. By contrast, null alleles cause no visibly abnormal phenotype, presumably as a consequence of the functional redundancy of unc-9...

Formation and Is Critical for Immunological Synapse Trafficking of Lck via the Rab11 Endosome Uncoordinated 119 Protein Controls

Genetic interactions between UNC-17/VAChT and a novel transmembrane protein in Caenorhabditis elegans.

The unc-17 gene encodes the vesicular acetylcholine transporter (VAChT) in Caenorhabditis elegans. unc-17 reduction-of-function mutants are small, slow growing, and uncoordinated. Several independent unc-17 alleles are associated with a glycine-to-arginine substitution (G347R), which introduces a positive charge in the ninth transmembrane domain (TMD) of UNC-17. To identify proteins that intera...

UNC-119 suppresses axon branching

Typically, mature neurons are polarized cells composed of a dendritic arbor and a single axon (reviewed by Craig and Banker, 1994; Higgins et al., 1997). This polarity becomes apparent early during development when the neuron extends a growth cone to form a single unbranched axon (reviewed by Goodman, 1996; Goodman and Tessier-Lavigne, 1997; Mueller, 1999). In some neuronal populations collater...

UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans.

After endocytosis, membrane proteins are often sorted between two alternative pathways: a recycling pathway and a degradation pathway. Relatively little is known about how trafficking through these alternative pathways is differentially regulated. Here, we identify UNC-108/Rab2 as a regulator of postendocytic trafficking in both neurons and coelomocytes. Mutations in the Caenorhabditis elegans ...